Finally, clonidine boosts neuraxial opioids and, together with fentanyl, interacts in an additive manner, which can lessen the dose of each element by 60% for postoperative analgesia.Jun ten, 2024 · If clonidine therapy is to get replaced by a β-blocker, hold off administration of your β-blocker for quite a few days following clonidine therapy
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